Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with poor prognosis, early recurrence, and the lack of durable chemotherapy responses and specific targeted treatments.The recent FDA approval for immune checkpoint inhibition in combination with nab-paclitaxel for the treatment of metastatic TNBC created oppo

Abstract Cognitive science invokes semantic networks to explain diverse phenomena, from memory retrieval to creativity.Research in these areas often assumes a single underlying semantic network that is shared across individuals.Yet, recent evidence suggests that content, size, and connectivity of semantic networks are experience-dependent, implying

Chronic low back pain (CLBP) is a debilitating, painful, and costly condition.Implantable neuromuscular electrical stimulation targeting the multifidus musculature is growing as a non-pharmacologic option for patients with recalcitrant nociceptive mechanical CLBP who have failed conservative treatments (including Accessories medications and physica

Abstract Background Facial Wash Functional cooperation between FACT and the MCM helicase complex constitutes an integral step during DNA replication initiation.However, mode of regulation that underlies the proper functional interaction of FACT and MCM is poorly understood.Methods & Results Here we present evidence indicating that such interaction